A variety of habitats ensures diverse and interesting game viewing. The wildlife depends largely on the water levels in the area. The lagoons are home to Hippo and Crocodile and the permanent waterways and floodplains attract large numbers of waterfowl. In the permanent waters, Sitatunga can be tracked silently by mokoro.
The largest concentrations of endangered Wattled Crane are found in this area. The birdlife is simply stunning: Slaty Egrets, Pink-throated Longclaws and African Skimmers are some of the specials that can be seen. Hippo, Sitatunga antelope and Crocodile reside in the deeper permanent lily-filled lagoons of the area. Lion, Leopard, Wild Dog, Cheetah, Tsessebe and Lechwe are among the major game attractions at Kwetsani. Nocturnal animals such as Porcupine, Aardwolf, Serval, Genet and Bushbaby can be observed on the night drives (water levels permitting).